Beilstein J. Org. Chem.2012,8, 1458–1478, doi:10.3762/bjoc.8.166
; kinetics; NHCactivation; organocatalysis; structure reactivity relationships; Review
Introduction
The most comprehensive nucleophilicity and electrophilicity scales presently available, are based on Equation 1, in which electrophiles are characterized by one solvent-independent parameter E, and
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Graphical Abstract
Figure 1:
Second-order rate constants for reactions of electrophiles with nucleophiles.